Have you been googling for ways to improve your hypothyroid or brain condition and come across suggestions to test MTHFR. What is MTHFR and what does it have to do with hypothyroidism or the brain? If you are one of the 60 percent of people with a genetic defect in the MTHFR gene, it could affect your ability to successfully manage Hashimoto’s hypothyroidism or brain-based symptoms.
MTHFR is the acronym for methylenetetrahydrofolate reductase, an enzyme involved in processing folate, or vitamin B9, into a usable form the body can assimilate. It’s also necessary to metabolize folic acid, a synthetic form of folate used in supplements.
Thanks to the popularity of gene testing, people can now learn whether they have a mutation in the MTHFR gene. If so, it means their methylation pathways are impacted and contributing to health challenges.
Methylation pathways govern detoxification and many important metabolic processes in the body, which makes a MTHFR defect something worth paying attention to. If you are struggling to manage your Hashimoto’s hypothyroidism or brain-based symptoms such as brain fog, fatigue, or depression, you may find the MTHFR test valuable.
Methylation is a process of adding a methyl group to a molecule. Methylation’s roles jobs include the following:
Turning genes on and off
Detoxifying chemicals and toxins from the body
Building brain neurotransmitters
Metabolizing hormones to maintain hormonal balance
Building immune cells
Synthesizing DNA and RNA
Creating cellular energy
Producing a protective coating that sheathes the nerves
Supporting eye health
Supporting liver health
Proper methylation means one can efficiently make proteins, use antioxidants, metabolize hormones, enjoy more balanced brain chemistry, detoxify toxins and heavy metals, and dampen inflammation. All of these factors are vital to managing Hashimoto’s hypothyroidism and brain-based symptoms.
However, if you’re one of the 60 percent of people with a MTHFR genetic defect, you may not be able to properly break down folate in foods or folic acid in supplements.
An inability to properly process folate can raise levels of homocysteine. Homocysteine is an amino acid in the bloodstream that can be dangerous when levels are too high. High homocysteine is linked to an elevated risk of heart disease and Alzheimer’s.
Poor methylation also impacts another vital process — the production of glutathione, the body’s main antioxidant. When we become deficient in glutathione, we lose our natural defenses and are at higher risk of developing autoimmune diseases, food sensitivities, and chemical sensitivities.
An MTHFR defect can also impair the body’s ability to synthesize important brain neurotransmitters, so that brain-based disorders may arise. An MTHFR defect has been linked to depression, anxiety, brain fog, ADHD, bipolar disorder, and even schizophrenia.
Because methylation is involved in so many important processes in the body, an MTHFR gene defect has been associated with many health conditions, including:
Inflammatory bowel disease
Mental and mood disorders
Autoimmune disorders such as Hashimoto’s hypothyroidism
If you are trying to manage a condition like Hashimoto’s hypothyroidism or brain-based symptoms, it’s imperative that you be able to dampen inflammation and raise glutathione levels. An MTHFR defect can work against you.
More than 50 MTHFR genetic mutations exist, but the two considered the most problematic are C677T and A1298C (written as just 677 and 1298).
Also, keep in mind gene defects don’t always become activated. If you show those genes on a test it doesn’t necessarily mean they have been expressed and are causing symptoms.
To address a MTHFR enzyme defect, support your methylation pathways with methylfolate and methylcobalamin (methyl B12). Avoid supplements with folic acid, boost your glutathione levels with high quality oral liposomal glutathione, and minimize your exposure to toxins. These are also beneficial strategies to aid in the management of Hashimoto’s hypothyroidism and brain-based symptoms.
Anyone who has learned how to manage Hashimoto’s hypothyroidism or another autoimmune condition will tell you they had to learn it on their own. The vast majority of doctors either do not test for or do not adequately treat Hashimoto’s, an autoimmune disease that attacks and damages the thyroid gland, causing weight gain, hair loss, fatigue, depression, and other symptoms. Now, the ability to find health advice backed by peer-reviewed, scientific literature is seriously compromised due to censorship, or blacklisting, by Google. Google is increasingly censoring legitimate information and instead sends people to conventional medical, pharmaceutical-oriented sources of information such as WebMd.
Most doctors do not adequately test for or treat autoimmune disease such as Hashimoto’s hypothyroidism because there is no drug for autoimmunity. True, people are prescribed thyroid hormone replacement medication, which is frequently necessary. However, it does not address the ongoing and progressively worsening immune attack on the thyroid gland. That is why many people do not feel better when they begin taking thyroid hormone.
The lack of adequate autoimmune care in conventional medicine means millions of people go misdiagnosed or undiagnosed. In most cases, autoimmune destruction has to be advanced and severe before an autoimmune disease can be diagnosed and treated with steroids, surgery, or other methods that are invasive and riddled with side effects and problems. For instance, nerve damage has to be significantly advanced before conditions such as multiple sclerosis or type 1 diabetes are caught, while patients suffer for years.
Add to this studies that show the inherent sexism in conventional medicine. Women account for more than three-quarters of autoimmune patients. Yet when women go their doctors with complaints of autoimmune symptoms, most are not adequately tested. Instead, they are told they have depression or anxiety, that they need to lose weight and exercise, that they are making it up, or that it’s just aging.
Until now, millions of people have been able to successfully learn how to manage their Hashimoto’s hypothyroidism and other autoimmune conditions through online sources based on peer-reviewed science. They have also been able to find healthcare practitioners who are knowledgeable in how to apply this science to help manage chronic conditions.
Please note that just because something is in the published scientific literature, that does not mean your local medical doctor is either aware of it or supports it. There is a huge gulf between the scientific literature and the doctor’s office, with pharmaceutical companies wielding significant influence over doctors’ practices and education.
Now, Google is limiting our access to legitimate information and redirecting searches toward conventional sources, which are extremely limited when it comes to chronic illness.
True, opportunists and snake oil salesmen abound on the internet and consumers must do their due diligence in rooting out valid sources of information and good communities to help them on their health journey.
Vitriolic corporate-driven public controversies lend a hand in the Google censorship. Rather than looking at the peer-reviewed literature on the links between environmental toxins and brain inflammation in the developing child’s brain for instance, complex neuroimmune topics have been reduced to crude black-and-white arguments that have no basis in relevant neurophysiological mechanisms.
While Google is penalizing many science-backed integrative health sites so they no longer show up on the first page, other search engines such as Bing, Yahoo, DuckDuckGo, and Ecosia (a search engine that plants trees based on searches) still rank sites legitimately.
About one billion health questions a day come through Google. Now, they are routing those searches away from such well-known sites as Mercola, PaleoHacks, Bulletproof, GreenMedInfo, Self-Hacked, Kelly Brogan, and many more.
Instead, seekers are routed to sites such as WebMD, Healthline, Mayo Clinic, and other institutional sites. While these sites offer worthwhile information, they are not yet caught up to the science surrounding the many chronic illnesses that have become so common today. They even provide false information in some instances, especially in regards to nutritional compounds.
Google is unfairly throwing its weight around in other industries as well, and the EU levied its third antitrust fine against Google earlier this year.
Don’t let Google bully you into Big Pharma’s pipelines. If you are looking for sources of legitimate health information that have been blacklisted by Google, try alternative sites such as Bing, Yahoo, DuckDuckGo, and Ecosia.
In the meantime, we attend educational conferences to stay up to date on the latest research and clinical protocols to help manage autoimmune and chronic conditions such as Hashimoto’s hypothyroidism. As the field is ever evolving, it’s important to stay abreast of developments. Contact my office if you need help managing your chronic health condition.
For many women, the onset of their hypothyroid symptoms began either during pregnancy or just after. Most of these women went on to be diagnosed with Hashimoto’s, an autoimmune disease that attacks and destroys the thyroid gland. Pregnancy often triggers Hashimoto’s due to normal shifts in immunity that cause an already beleaguered immune system to tip out of control and begin attacking the thyroid gland.
Factors that can contribute to developing Hashimoto’s around pregnancy or childbirth include shifts in immune function during the third trimester, shifts in immune function postpartum, the dramatic shifts in hormone function, genetic tendency, and the exacerbation of existing disorders such as blood sugar imbalances, food intolerances, gut infections, and other autoimmune diseases (which may or may not be diagnosed).
How pregnancy can trigger Hashimoto’s hypothyroidism
Women make up the vast majority of people struggling with autoimmune diseases, about 75 percent. Researchers suggest this is because women have more complex hormonal systems that involve more fluctuations; hormone and immune function are closely tied. Hormone imbalances are a major contributor to chronic inflammation that can trigger autoimmunity.
Pregnancy simply exacerbates these fluctuations and underlying imbalances.
Shifts in immune function during and after pregnancy can trigger autoimmune disease
Women experience major immune shifts towards the end of pregnancy and then again immediately after birth. These are natural shifts designed to help protect the baby.
During the third trimester, a pregnant woman’s immune system becomes more heavily weighted toward what is called the TH-2 system. This arm of the immune system is the delayed immune reaction that produces antibodies that identify a foreign invader a short while after it enters the body. This response allows the body to recognize the invader in the future.
After the baby is born, a woman’s body then becomes more TH-1 dominant. This is the arm of the immune system that reacts immediately to a foreign invader, such as with swelling and pus around a splinter.
Most people who either already have an autoimmune disease or are at high risk of developing one are overly dominant in either the TH-1 or TH-2 arms of the immune system.
The immune swings that pregnancy and childbirth cause tip an already imbalanced immune system into full expression of an autoimmune disease such as Hashimoto’s hypothyroidism.
Although about 90 percent of hypothyroid cases are caused by Hashimoto’s, some cases are caused by chronic stress. As any mom can tell you, pregnancy and childbirth can bring inordinate amounts of stress.
Extreme or chronic stress depresses function of the pituitary gland. The pituitary gland is a small gland at the base of the brain that is like a control tower for the body’s hormones, telling the various glands throughout the body how much hormone to secrete in response to external and internal cues.
Chronic stress overwhelms the pituitary gland and depresses its function. As a result, the pituitary falters at its job of telling the body’s hormone glands to secrete hormones. In the case of the thyroid gland, this means it doesn’t tell it to release enough thyroid hormone.
This not only causes tiredness and other hypothyroid symptoms, but it can also explain postpartum depression in some women.
It’s important to understand that stress doesn’t just mean bad traffic or a demanding job. Many women enter into pregnancy already under enormous stressors they may not be aware of:
Leaky gut or gut infections
Blood sugar that is either too low (hypoglycemia) or too high (insulin resistance)
Undiagnosed food intolerances such as gluten sensitivity or celiac disease
Undiagnosed brain dysfunctions, such as from an old brain injury, brain inflammation caused by poor diet, or PTSD or CPTSD
Sensitivity to chemicals or over exposure to chemicals
Poor liver detoxification
Undiagnosed chronic bacterial, viral, parasitic, or fungal infections
Are you at risk? Check your TPO and TGB antibodies before pregnancy
It’s not a bad idea to screen for risk for Hashimoto’s before conceiving. You can do this by testing TPO and TGB antibodies. Many people have autoimmune mechanisms already in place that not advanced enough to cause symptoms. However, a big shock to the body such as pregnancy can be the tipping point to send you over the edge into autoimmune expression.
If you have Hashimoto’s in your family, other autoimmune diseases in your family, or you suffer from other inflammatory conditions, it pays to screen for your risk before pregnancy. This gives you an opportunity to use functional medicine strategies to slow down or send into remission your autoimmune condition.
Studies show that women with no thyroid symptoms but positive blood serum TPO antibodies have a 25 percent higher risk for developing an autoimmune response to their thyroid.
Reducing the risk of autism, allergies, eczema, and more in your baby
Using functional medicine to manage autoimmunity or heightened risk for autoimmunity is not only good for the mother’s health, but also for that of her child. Children born to mothers with autoimmunity such as Hashimoto’s show increased risk for varying health disorders, including autism spectrum disorder, eczema, asthma, food allergies, and food intolerances.
Researchers have increasingly found that autoimmune disorders underlie many cases of autism, which is caused by an autoimmune attack against the brain in these children. Whether it’s autism or other immune disorders, children born to mothers with imbalanced immune systems may be more vulnerable to environmental triggers that can tip them over into full blown autoimmunity.
Triggers can include food intolerances, blood sugar imbalances, or toxic chemicals introduced into the bloodstream.
Of course, no one willingly or knowingly brings these hardships onto themselves or their children, but in today’s world the modern immune system faces significant burdens. Going into pregnancy knowing how to manage and minimize the impact of those burdens on the body can help minimize the risk. If you already developed Hashimoto’s during pregnancy or after childbirth, understanding why you did can help you better manage it.
Ask my office for help addressing the root cause of your Hashimoto’s hypothyroidism.
Numerous studies show a strong link between gluten intolerance and Hashimoto’s disease, an autoimmune disease that attacks the thyroid gland, causing hypothyroidism. This is because gluten has a molecular structure that closely resembles thyroid tissue — gluten sensitivity triggers an attack on the thyroid gland. Gluten (technically, the correct term is gliadin), is the protein found in wheat and wheat-like grains, such as spelt, kamut, rye, barley, triticale, and oats.
One of the immune system’s primary jobs is to protect the body from foreign invaders. Sometimes it may recognize a common food as a dangerous invader. When you eat that food throughout each day this can keep your immune system engaged in constant battle, making it hyper zealous, overly sensitive, and thus prone towards food sensitivities and autoimmunity.
Some people also have celiac disease, disease in which gluten triggers an autoimmune attack against the gut, the skin, or neurological tissue. Gluten sensitivity is more common than celiac disease, however, both show up in higher numbers in people with Hashimoto’s hypothyroidism.
If you have been diagnosed with hypothyroidism you should first test for Hashimoto’s by screening for TPO and TGB antibodies — the majority of hypothyroidism cases are caused by Hashimoto’s.
You should also screen for gluten intolerance or celiac disease given how common these conditions are in patients with Hashimoto’s. Likewise, people who discover they are gluten intolerant or have celiac disease should screen for Hashimoto’s.
It’s important to give up gluten completely if you have Hashimoto’s and gluten intolerance. Cheats and little bites are not ok as they trigger an immune response that ultimately destroys thyroid tissue. Also, it’s important to avoid foods that have been contaminated by gluten. Be careful when in a kitchen where gluten is used, with restaurant food, or with questionable packaged foods.
Cyrex Labs offers testing to identify gluten intolerance. However, sometimes the immune system can be so depleted that it produces too few antibodies to produce a positive test, even though you react to gluten. You can screen for this with a total immunoglobulin test.
However, given the evidence establishing a link between gluten intolerance and Hashimoto’s disease, you may be surprised how much better you feel by simply removing gluten from your diet as a start.
Many people have to remove other foods as well, such as dairy, eggs, or other grains. Following the autoimmune paleo diet for about a month and then reintroducing restricted foods one at a time every 72 hours can help you determine which foods trigger an inflammatory reaction in you.
Many people are able to put their hypothyroid symptoms into remission simply by following a diet that eliminates gluten and other trigger foods. Although autoimmune diseases such as Hashimoto’s can be successfully managed through diet and lifestyle strategies, it’s important to understand they can’t be cured. It’s just a matter of taming the immune system.
Ask my office for ways to manage your autoimmune Hashimoto’s hypothyroid condition.
When it comes to autoimmune Hashimoto’s hypothyroidism, dampening inflammation and immune attacks on the thyroid is the primary goal. One of the most powerful allies in this quest is to support your regulatory T cells (T reg cells). These are immune cells that do what their name implies — they help regulate the immune system. This means they play a role in either activating or dampening inflammation. The good news is that when it comes to Hashimoto’s, we can do many things to influence the T reg cells to dampen inflammation and quell Hashimoto’s flare ups and attacks so you can have more good days.
Ways to support T reg cells to manage Hashimoto’s
If you would like help understanding ways to support T Reg Cells to manage Hashimoto’s, you can schedule a FREE 15-MINUTE CONSULTATION with Dr. Celaya.
Following are some proven ways we can support our T reg cells to manage Hashimoto’s.
Vitamin D (cholecalciferol). Fat soluble vitamin D is a powerful supporter of the T reg cells, especially at therapeutic doses (around 10,000 IU a day).
Vitamin D is also important because studies show many people with Hashimoto’s have a genetic defect hindering their ability to process vitamin D. Therefore, they need higher amounts of vitamin D to maintain health. This can be the case even if a blood test shows sufficient levels of serum vitamin D. That’s because the defect is at the cellular receptor site, preventing vitamin D from getting into the cells.
Omega 3 fatty acids. The EPA and DHA in fish oil support T-reg cells. It’s important to make sure you take enough; it’s estimated 80 percent of the population are deficient in essential fatty acids.
Research shows a healthy dietary intake of supplemental omga-3 is 3,500 mg if you eat 2,000 calories per day.
The average EFA capsule is 1,000 mg. Most people in the US eat between 2,000 to 3,000 calories a day and therefore should take 4 to 6 capsules of fish oil a day. Dietary sources of omega 3 include cold water fish, nuts, and seeds.
Glutathione. Glutathione, also known as the master antioxidant, supports T reg cells and is a powerful support in dampening inflammation and managing Hashimoto’s. Straight glutathione cannot be absorbed well but there are other ways to take it, including reduced glutathione, s-acetyl-glutathione, liposomal glutathione, and glutathione precursors.
Glutathione precursors make glutathione inside the cells and include n-acetyl cysteine, cordyceps, Gotu Kola, milk thistle, and alpha lipoic acid. Don’t be shy to take large amounts of glutathione support to dampen inflammation.
Short chain fatty acids (SCFAs). SCFAs are powerful signaling compounds that influence the health of the body and brain. They are produced by healthy gut bacteria that come from eating a diet abundant in a diverse array of vegetables. The more abundant and diverse your gut bacteria the better your SCFA production.
This helps many functions in your body, including proper T reg cell function and dampening of inflammation and managing Hashimoto’s. You can also take the SCFA butyrate to support your SCFA levels, however, you’ll need to make sure you’re eating plenty of vegetables throughout the day too for this strategy to be effective.
Endorphins. Saving the best for last, did you know a powerful way to support anti-inflammatory function of T reg cells is to experience joy, happiness, love, and playfulness? All of these things produce endorphins, feel good chemicals that reduce inflammation. Methods for increasing endorphins include:
Socializing regularly with healthy people
Meditation and breath work
Massage and other forms of body work
Doing something playful regularly
Daily expression of gratitude via a journal or verbal affirmation
Regular exercise that gives you a “natural high” but doesn’t wear you out
These are some of the ways you can manage your Hashimoto’s hypothyroidism. Ask my office for more information.
Have you ever wanted to know everything there is to know about your thyroid? This 7-part video series will cover thyroid lab testing, nutrition and infections that affect the thyroid, toxins, thyroid hormone conversion, lifestyle, and adrenal interplay.