• Ingredients: Rice Bran Oil‚ USP Progesterone, Vitamin E (with mixed tocopherols).
  • Progesterone per Drop: 4.0 mg.
  • Topical Oil.
  • 50% more product than the competition and in its own dedicated formula.

Balancing Female Hormones

Progesterone is important throughout a woman’s life, but it’s especially needed during her childbearing years. Low progesterone levels may cause irregular periods and make it harder to become pregnant or maintain a pregnancy.

Pro-Adapt helps provide relief from irregular periods and a myriad of other symptoms. It contains clinically significant amounts of progesterone in an oil-based formula that mimics that of the body’s own naturally produced hormones.


Progesterone works hand-in-hand with estrogen. One of the reasons why many women are low in progesterone is because they have high estrogen levels. Taking Pro-Adapt may help reestablish a balance between the two hormones to provide relief for women with heavy menstrual periods. Unlike other brands, BioMatrix separates its progesterone and estriol products, allowing for precision dosing and optimal results.

  • USP Progesterone is responsible for regulating the menstrual cycle, pregnancy, and embryo development. It is produced in the corpus luteum of the ovaries each month after a woman ovulates, and helps prepare for a fertilized egg directly after ovulation by thickening the lining of the uterus. BioMatrix progesterone is derived from an extraction of the steroidal backbone of the Mexican Wild Yam (Dioscorea villosa). It is bioidentical, which means it possesses the same molecular structure as that produced naturally by the body.

  • Vitamin E (mixed with tocopherols) is a blend of natural-source alpha-tocopherol and mixed tocopherols. An independent assay of a leading brand of oil-based hormones determined that only one form of vitamin E (tocopheryl acetate) is included in their formula. Acetate is cheap acid, used in wood glue. In contrast, BioMatrix Est-Adapt uses premium vitamin E in mixed tocopherol forms for enhanced stability and oxidative protection.

  • Rice Bran Oil is a reliable oil carrier which contributes to the stability and viscosity of numerous formulas.


How many drops of oil are in each bottle?

There are approximately 500 drops per bottle (at a price lower or equal to the competition, with 50% more product per bottle).

Why is the bottle only partially full?

The oil fills approximately 1/3rd of the bottle to allow for adequate shaking of the product before use, and to accommodate the glass pipette’s length and width.

What are some tips for handling the bottle?

  • Shake vigorously before use. If the oil seems to adhere to the bottom, slap the bottle on your palm a few times to loosen it, then shake vigorously. You can also dip the bottle in hot water for a few minutes to loosen contents after a period of not being used.

  • To best observe how much oil is left in your bottle, hold it up to bright light and tilt the bottle sideways. The dark amber glass bottle is used for protecting the oil and increasing stability.

  • Tilt the bottle and insert the dropper’s pipette to get every drop out of your bottle, as needed.

How do BioMatrix oil-based hormones differ from other leading brands?

Many BioMatrix customers have used Phyto-BL 4X™ and Progon-BL 4X™ and requested information comparing our new products, especially in terms of converting dosages. While similar in intent and purpose, there are some fundamental differences – and similarities – between Est-Adapt™ and Pro-Adapt™, and these other products.

Strength per Drop

  • Pro-Adapt and the equivalent progesterone product deliver the same amount of progesterone per drop. Pro-Adapt is an equivalent replacement for Progon-BL 4X. Both products deliver 4.0 mg per drop.

  • Est-Adapt is an estriol-only formula, maximizing dosing options and clinical success. Est-Adapt contains 0.5 mg per drop of estriol while the competing product contains 0.2 mg per drop. Refer to the dosing guidelines and conversion table below.

  • Other brands combine estriol and progesterone in the same formula, negating the opportunity for precision dosing and specific symptom management. This creates limitations for addressing common clinical needs and eliminates the option to use estriol on its own. For example, if a woman needs an additional 10 mg of estriol and is taking the combination product, they would be getting an extra 200 mg of progesterone, which is certainly contraindicated in the majority of cases.

Oil Base

BioMatrix’ vitamin E oil base is a blend of natural-source alpha-tocopherol and mixed tocopherols. An independent assay of the leading brand of oil-based hormones resulted in determination that only one form of vitamin E (the cheapest one, acetate) is included in the formula. BioMatrix uses vitamin E in mixed tocopherol form for enhanced stability.

Why not combine progesterone and estriol in one formula (like some other brands)?

What makes Est-Adapt special is its ability to be administered with precision. Each woman is unique with her own needs.

  • Fine-tuning dosages of each hormone is not possible if estriol and progesterone are combined in fixed amounts. With estriol and progesterone in their own bottles, the possibilities for precise dosing are boundless.

  • When only estriol is needed, the other brand’s combination product cannot be used without significantly overdosing progesterone. This is especially important in premenopausal women given their unique needs for timing and distribution during the menstrual cycle. For example, with salivary hormone testing which maps the cycle for estriol and progesterone levels over weeks, it may be determined that a woman is low on both hormones throughout the cycle. In order to prevent suppressing ovulation, her hormone augmentation would require estriol-only supplementation early in the follicular phase. If progesterone were administered at that same time, ovulation would be suppressed, potentially rendering her infertile for that cycle.

  • Another advantage to separating each hormone into its own formula, is the ability to target symptoms at specific times of the day. For instance, estriol is known to have a more energizing effect than progesterone, which has more calming effects. Therefore, a woman using both hormones may choose to use estriol in the morning while using progesterone in the evening. And in the case of addressing hot flashes and the times they often occur, separately administering these hormones can improve the chances of symptom relief. This flexibility for targeting symptom relief is not possible with a combination formula.

How do I convert dosages from the competing combo brand to Est-Adapt and Pro-Adapt?

The following chart explains how to convert dosing from the Phyto-BL 4X combination formula to BioMatrix’ precision-dosing formulas, using examples of common dosages. See the FAQ item above to better understand why separating the hormones into their own bottles is so critical to optimal care. It not only allows for sequencing and titration, but also has numerous advantages for addressing specific symptoms.

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